Investigations involving live subjects

All investigations involving humans must be conducted in accordance with the principles embodied in the Declaration of Helsinki and in accordance with local statutory requirements. Articles relying on clinical trials should quote the trial registration number at the end of the abstract. IOP also encourages the registration of such studies in a public trials registry prior to publication of the results in the journal. All investigations involving animal experimentation must be conducted in accordance with the Guiding Principles for Research Involving Animals and Human Beings as adopted by the American Physiological Society, and with local statutory requirements.